el Envío 1

Envío 1

Abstract

Transfusion-transmitted viral infections, such as those caused by hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and adult T-cell lymphotropic virus (HTLV), continue to be a public health problem, primarily in developing countries. Monitoring serological markers of infection in blood donors can reflect their burden in the general population. In this context, the study aimed to determine their prevalence and trends over time. Records from the National Blood Services System of the Ministry of Public Health and Social Welfare for the period 2006–2023 were used. Trends were obtained using simple regression, and changes in trends were assessed using joinpoint trend analysis. A total of 1.538.767 records of adult donors aged 18–65 years from the country's blood services were included in this study. For all viral markers, the highest seroprevalence was found in males. Declining trends were observed for the anti-core markers for hepatitis B (r2=0.88; p<0.0001) and HIV (r2=0.59; p=0.002), a slight decline in HBsAg (r2=0.21; p=0.0565), and a stable trend for hepatitis C virus (r2=0.00; p=0.9362) and HTLV (r2=0.02; p=0.5981). Turning points in the trend were estimated for HBsAg in 2021, for HCV in 2009, and for HIV in 2012 and 2018.